Normal development of the nervous system is achieved through an elaborate program of guided neuronal migration and axonal growth. In the last few years, a flood of research has dissected the molecular bases of these phenomena, and several cell‐surface and extracellular matrix molecules, which are implicated in neuronal and axonal targeting processes, have been recognized. Taking this knowledge a step further, a recent paper by Tom Curran's group(1) reports the molecular cloning of the gene deleted in the autosomal recessive mouse (...) mutation reeler, affecting cortical neuronal migration. This gene encodes reelin, a novel extracellular matrix protein. (shrink)

The article examines the impact of digitalization on human life and intellectual experience. The development of computer technology demands an understanding of new aspects of human development and requires a capability to overcome not only external conditions but also ourselves. Entering a new level of development cannot imply a complete rejection of previous dispositions, but should be accompanied by reflection on personal experience and by the quest for new forms of interaction in society and with nature. Communicative and cognitive activity (...) of a person has an ontological basis and relies on processes that actually evolve in nature. Therefore, the creation of new objects is always associated with the properties of natural material and gives rise to new points of support in the development of man. The more audacious his projects, the more important it is to preserve this connection to nature. It is always the human being who turns out to be the initiator who knows how to solve problems. The conformity of complex technical systems to nature is not only a goal but also a value of meaningful construction of development perspectives. The key to the nature orientation of the modern digital world is the human being himself, who keeps all the secrets of the culture of his natural development. Therefore, the proposed by the Russian philosopher V.S. Stepin post-non-classical approach, based on the principle of “human-sizedness,” is an important contribution to contemporary research because it draws attention to the “human – machine” communication, to the relationship between a person and technological systems he created. The article concludes that during digital transformation, a cultural conflict arises: in an effort to solve the problems of the future, a person equips his life with devices that are designed to support him, to expand his functionality, but at the same time, the boundaries of humanity become dissolved and the forms of human activity undergo simplification. Transhumanism engages society in the fight against fears of vulnerability and memory loss and ignores the flexibility and sustainability of natural foundation. (shrink)

This study investigates the online process of reading and analyzing of sketchnotes (visual notes containing a handwritten text and drawings) on Russian language material. Using the eye-tracking method, we compared the processing of different types of sketchnotes (‘path’ (trajectory), linear, and radial) and the processing of a verbal text. Biographies of Russian writers were used as the material. In a preliminary experiment, we asked 89 college students to read the biographies and to evaluate each text or sketch using five scales (...) (from -2 to +2). The best example for each of three formats of sketchnotes and a verbal text were chosen. In the main experiment, twenty-one secondary school students examined four different biographies in four different formats (three sketchnotes and a verbal text), answered to the factual and analytical questions to these texts and estimated the difficulty of each text. We measured the total dwell time, the total fixation count, the average fixation duration for each stimulus as well as for separate zones inside the sketches including verbal and non-verbal information. Our results show that readers process the information better and faster while reading sketchnotes than a verbal text. In the trajectory sketchnotes, the readers followed the order of elements aimed by the author of the sketchnotes better than in the radial and linear sketchnotes. The analysis of participants’ eye movements while processing the stimuli made it possible to propose several recommendations for creating effective sketchnotes. (shrink)

Aging is associated with decreased functional connectivity in the main brain networks, which can underlie changes in cognitive and emotional processing. Neurofeedback is a promising non-pharmacological approach for the enhancement of brain connectivity. Previously, we showed that a single session of infra-low frequency neurofeedback results in increased connectivity between sensory processing networks in healthy young adults. In the current pilot study, we aimed to evaluate the possibility of enhancing brain connectivity during aging with the use of infra-low frequency neurofeedback. Nine (...) females aged 52 ± 7 years with subclinical signs of emotional dysregulation, including anxiety, mild depression, and somatoform symptoms, underwent 15 sessions of training. A resting-state functional MRI scan was acquired before and after the training. A hypothesis-free intrinsic connectivity analysis showed increased connectivity in regions in the bilateral temporal fusiform cortex, right supplementary motor area, left amygdala, left temporal pole, and cerebellum. Next, a seed-to-voxel analysis for the revealed regions was performed using the post- vs. pre-neurofeedback contrast. Finally, to explore the whole network of neurofeedback-related connectivity changes, the regions revealed by the intrinsic connectivity and seed-to-voxel analyses were entered into a network-based statistical analysis. An extended network was revealed, including the temporal and occipital fusiform cortex, multiple areas from the visual cortex, the right posterior superior temporal sulcus, the amygdala, the temporal poles, the superior parietal lobule, and the supplementary motor cortex. Clinically, decreases in alexithymia, depression, and anxiety levels were observed. Thus, infra-low frequency neurofeedback appears to be a promising method for enhancing brain connectivity during aging, and subsequent sham-controlled studies utilizing larger samples are feasible. (shrink)

Marina Gustavovna Shtorkh is a daughter of Gustav Shpet (1879-1937), one of the most important Russian philosophers of the 20th century. He spent the last two years of his life (1935-1937) in exile in Siberia. M.G. Shtorkh shares her memories in a documentary film about her father and his circle, the intellectual leaders of the Silver Age, philosophers, actors, artists: A. Belyi, V. Kachalov, I. Moskvin, A. Shchusev, B. Pil`niak, etc. This book by Elena Iakovich is a transcript of (...) the film. (shrink)

From its inception to the 4th century CE, Christianity experienced a formative process composite of three catalytic phases characterised by distinctive events (i.e. Jewish-Christian Schism, Hellenism and imperial intervention). From the aforementioned era emerged an orthodoxy fostered by an imperial-ecclesiastical link. There appears to have been a parallel story with regard to certain elements of African Christianity, in particular, Ethiopian Christianity. What can be made of the gap regarding Jewish Christianity combined with the absence of African Christianity from Bauer’s modular (...) theory on heresy and orthodoxy in the development of early Christianity? Despite the dominant story of the development of an imperial religious establishment at the turn of the 4th century, could there be an alternative narrative to Christianity in the African region derivate from Ethiopia? Reviewing the emergence of a religious political Christianity in this era as modular against Ethiopian Christianity in tangent with its links with Christianity in Roman Africa, establishment of the nature and development of Ethiopian Christianity was performed. This was performed through documentary analysis. Bauer’s (1971) theory of orthodoxy and heresy in early Christianity did not exhaustively account for Jewish Christianity and North African distinct intransigent tradition characteristic of Carthage. By extension to African Egyptian, Alexandria is Ethiopian Christianity that was characterised by Judaic tradition in contrast to anti-Judaism. This established a parallel history of Christianity in Africa inclusive of Ethiopia. A review of this perspective contains contemporary momentum in view of the focus on Ethiopian Jews, for example, as religious praxis was as important as ethnicity in determining the Jewishness of whole tribes. (shrink)

The article describes two approaches to modeling the concept system of science – the thematic and paradigm ones. The re­search represents a case study of the two corpuses of abstracts: abstracts of projects supported by the Department of Humanities and Social Sciences of the Russian Federal Property Fund in lin­guistics, as well abstracts of articles by authors (and their co-au­thors) who have received multiple support from this foundation. Thematic modeling was carried out within the frameworks of two approaches: сcorpus based (...) approach (modeling the system of concepts as a holistic entity of term fields network), and single text approach (singling out compositions of term fields steadily present in the texts of projects which can be treated as separate branches of linguistics). The method of semantic graph modeling realized in the “Semograph” Information system (corpus based approach) and the K-means clustering method (single text based approach) were applied. Arrays of keywords (those that occurred in the abstracts of projects supported by the Foundation) grouped into term fields served as operational units. Paradigmatic model­ing was based on the analysis of network interaction of research­ers (created on the basis of the information on joint publications). After the hypergraph of researchers (2,108 state points) had been created, it was divided into subgraphs (network communities) by means of the modularity method (analogue of cluster analysis). Each cluster can be considered as a model of a scientific commu­nity that actualize a certain scientific paradigm; a set of clusters represents a model of the concept system of a certain subject domain from the point of view of representation and interrela­tion of several paradigms. The synthesis of thematic and paradig­matic models appears to be the direction for future research that involves modeling the concept system of science. The considered models can be applied as an effective means of monitoring, fore­casting and managing scientific research, i.e. as an instrument of state and/or department policy. (shrink)

The objective of the current study was to propose a sensitivity analysis of a 3D left ventricle model in order to assess the influence of parameters on myocardial mechanical dispersion. A finite element model of LV electro-mechanical activity was proposed and a screening method was used to evaluate the sensitivity of model parameters on the standard deviation of time to peak strain. Results highlight the importance of propagation parameters associated with septal and lateral segments activation. Simulated curves were compared to (...) myocardial strains, obtained from echocardiography of one healthy subject and one patient diagnosed with intraventricular dyssynchrony and coronary artery disease. Results show a close match between simulation and clinical strains and illustrate the model ability to reproduce myocardial strains in the context of intraventricular dyssynchrony. (shrink)

This essay argues that according to feminist existential phenomenology, feminist pragmatism, and feminist genealogy, our embodied condition is an important starting place for ethical living due to the inevitable role that habits play in our conduct. In bodies, the phenomenon of habit uniquely holds together the ambiguities of freedom and determinism, transcendence and immanence, and stability and plasticity. Seeing habit formation as a matter of self-growth and social justice gives fresh opportunity for thinking of “assuming ambiguity” as a lifelong endeavor (...) made up of many small projects and practices of situated resistance to stagnation. Transcendence, understood as ameliorative transformation, is found in cultivating habits of learning from our bodily living. I articulate this argument via a reading of Simone de Beauvoir's The Coming of Age, John Dewey's Human Nature and Conduct, and Ladelle McWhorter's Bodies and Pleasures. I discuss two domains wherein the ethical significance of habit formation appears: cognitive psychological research on neural plasticity, and certain projects of self-cultivation that risk turning into overdetermining “cult of the self ” practices that close off possibilities for personal and collective transformation. (shrink)

Coordination is a widely employed term across recent quantitative and qualitative approaches to intersubjectivity, particularly approaches that give embodiment and enaction central explanatory roles. With a focus on linguistic and bodily coordination in conversational contexts, I review the operational meaning of coordination in recent empirical research and related theorizing of embodied intersubjectivity. This discussion articulates what must be involved in treating linguistic meaning as dynamic processes of coordination. The coordination approach presents languaging as a set of dynamic self-organizing processes and (...) actions on multiple timescales and across multiple modalities that come about and work in certain domains (those jointly constructed in social, interactive, high-order sense-making). These processes go beyond meaning at the level that is available to first-person experience. I take one crucial consequence of this to be the ubiquitously moral nature of languaging with others. Languaging coordinates experience, among other levels of behavior and event. Ethical effort is called for by the automatic autonomy-influencing forces of languaging as coordination. (shrink)

This is the review paper for the section III ("Symmetry breaking") of the volume "Symmetries in physics: philosophical reflections", Cambridge University Press, 2003, edited by Katherine A. Brading and Elena Castellani. The paper's sections are: 1. Preliminaries (I); 2. Symmetry breaking and Curie's analysis; 3. Preliminaries (II); 4. Symmetry breaking of physical laws (4.1. Explicit symmetry breaking; 4.2. Spontaneous symmetry breaking); 5. Symmetry breaking and philosophical questions.

This essay frames systemic patterns of mental abuse against women of color and Indigenous women on Turtle Island (North America) in terms of larger design-of-distribution strategies in settler colonial societies, as these societies use various forms of social power to distribute, reproduce, and automate social inequalities (including public health precarities and mortality disadvantages) that skew socio-economic gain continuously toward white settler populations and their descendants. It departs from traditional studies in gender-based violence research that frame mental abuses such as gaslighting--commonly (...) understood as mental manipulation through lying or deceit--stochastically, as chance-driven interpersonal phenomena. Building on structural analyses of knowledge in political epistemology (Dotson 2012, Berenstain 2016), political theory (Davis and Ernst 2017), and Indigenous social theory (Tuck and Yang 2012), I develop the notion of cultural gaslighting to refer to the social and historical infrastructural support mechanisms that disproportionately produce abusive mental ambients in settler colonial cultures in order to further the ends of cultural genocide and dispossession. I conclude by proposing a social epidemiological account of gaslighting that a) highlights the public health harms of abusive ambients for minority populations, b) illuminates the hidden rules of social structure in settler colonial societies, and c) amplifies the corresponding need for structural reparations. (shrink)

AfterTranscritique: On Kant and Marx, Karatani Kōjin’s new bookThe Structure of World Historypresents another engagement with Marxian theory from a ‘heterodox’ standpoint. In this book, rather than viewingThe Structure of World Historyfrom the aspect of mode of production in the conventional ‘Marxist’ sense, Karatani shifts perspective to the modes of exchange. To this end, Karatani appropriates what he sees as Marx’s emphasis on ‘exchange’. In the present essay, by looking at the textual evidence, I critically evaluate whether this appropriation of (...) Marx’s theory is justified. I furthermore contend that Karatani’s reading of the concepts of value, money, capital, and surplus-value from the standpoint of ‘exchange’ arises from a grave misconstrual of Marx’s critical intent. Accordingly, Karatani neglects the critique of exploitation and the systematic production of poverty that informs the basic assumptions of Marx’s analysis of the capitalist mode of production. (shrink)

The justification of democracy, while widely debated, is hindered by a sub-optimal conceptual framework. For a start, there is confusion about the basic terms in the discussion. Many theorists claim to support either the ‘intrinsic’ or the ‘instrumental’ value of democracy, but it is unclear what this exactly means. Can democracy have other kinds of values? What does it mean to value democracy intrinsically? As a result, at certain points, scholars are talking past one another and their assessments of their (...) respective approaches to democracy are less clear than what they intended. This paper develops a conceptual framework of the values of democracy. I use this framework to classify theories of democracy under three main groups: theories that value democracy intrinsically, instrumentally, or contributorily (necessarily and non-necessarily). Through this analysis, the points of engagement among the different approaches will emerge and flawed arguments about democracy will be revealed. (shrink)

The question whether AI systems have agency is gaining increasing importance in discussions of responsibility for AI behavior. This paper argues that an approach to artificial agency needs to be teleological, and consider the role of human goals in particular if it is to adequately address the issue of responsibility. I will defend the view that while AI systems can be viewed as autonomous in the sense of identifying or pursuing goals, they rely on human goals and other values incorporated (...) into their design, and are, as such, dependent on human agents. As a consequence, AI systems cannot be held morally responsible, and responsibility attributions should take into account normative and social aspects involved in the design and deployment of the said AI. My argument falls in line with approaches critical of attributing moral agency to artificial agents, but draws from the philosophy of action, highlighting further philosophical underpinnings of current debates on artificial agency. (shrink)

The importance of emotions is supported by many authors of the ethics of care in contrast to the rationalistic paradigm of justice. However, the reference to the emotions remains generic. By focusing on three paradigmatic typologies, I propose to investigate this aspect further, and distinguish between the different emotions that motivate care. I will try, first, to offer a reflection on which emotions are likely to motivate ethical action within an ethics of care; second, to survey different potential obstacles to (...) these emotions and propose how they might be overcome to more successfully achieve good care and ethical action. (shrink)

Fictions feature prominently in several of Hume’s important arguments about the external world. For example, Hume is clear that there would be no belief in the continued existence of objects, were it not for the fictions that are causally responsible for effecting this belief. Interpreters of Hume on the topic of fiction generally argue that the formation of fiction requires the possession of general ideas and the use of language. Drawing upon recent attempts in the literature to advance this claim, (...) I offer reasons for why this general approach is undesirable. By examining Hume’s comments on the capabilities of children, this paper advances a novel approach to the topic of fictions in Hume’s philosophy that separates the matter of fiction formation from the use of language, arguing instead that it is not the use of language that establishes fictions; fictions exert their influence upon the mind before the use of language becomes available to us. (shrink)

It has been a long-standing puzzle that Negative Polarity Items appear to split into two subvarieties when their effect on the interpretation of questions is taken into account: while questions with any and ever can be used as unbiased requests of information, questions with so-called `minimizers', i.e. idioms like lift a finger and the faintest idea, are always biased towards a negative answer (cf. Ladusaw 1979). Focusing on yes/no questions, this paper presents a solution to this puzzle. Specifically it is (...) shown that in virtue of containing even (cf. Heim 1984), minimizers, unlike any, trigger a presupposition, which reduces the set of the possible answers to a question to the singleton containing the negative answer. (shrink)

This paper investigates Negative Concord, arguing that it results from a systematic lexical ambiguity: the items that participate in Negative Concord ("n-words" in Laka's 1990 terminology) are ambiguous between negative polarity items and their genuinely negative counterparts. I try to show that on empirical grounds the proposed account compares favorably with other analyses that shy away from ambiguity. I furthermore suggest that the ambiguity is not implausible conceptually because it can be viewed as reflecting an intermediate stage of the Jespersen (...) Cycle. Negative Concord can be observed in many languages. The data discussed here are taken from Romance, primarily Spanish. (shrink)

The Congress for Cultural Freedom is remembered as a paramount example of the “cultural cold wars.” In this paper, I discuss the ways in which this powerful transnational organization sought to promote “science studies” as a distinct – and politically relevant – area of expertise, and part of the CCF broader agenda to offer a renewed framework for liberalism. By means of its Study Groups, international conferences and its periodicals, such as Minerva, the Congress developed into an influential forum for (...) examining the ways Big Science impacted the relations between science, society, and politics, thus constituting a semi-institutional niche for Science Studies before its professionalization within academia during the 1970s. I argue that the Congress contributed to the construction of public space in which the relations between science, society and politics were debated, and science was reconceptualized as a social activity. The vision of “science studies” the CCF-associated intellectuals promulgated was different from the science studies we know today. Yet, this alternative vision, in which the issues of science politics appeared inseparable from those of science policy, science organization, and science governance, constituted the “pre-history” of science studies today. (shrink)

The article discusses Karl Popper’s account of Lamarckism. In this article I use Popper’s published and unpublished statements regarding Lamarckism as well as his correspondence with the Australian immunologist Edward Steele and other biologists to examine why Popper was interested in Lamarckism, how his account of Lamarckism can be understood in the context of his philosophy, and what, if any, new context Popper provided for the discussion of this abandoned doctrine. I begin by discussing Popper’s frame of reference regarding Lamarckism, (...) examining how it changed following his involvement with different “transitory groups” of biologists concerned with redefining the boundaries between traditional disciplines. I then discuss Popper’s account of Lamarckism in positioning it in relation to three aspects of his philosophy: his distinction between the principles of induction/instruction and deduction/selection, his distinction between scientific and teleological concepts, and his concept of progress in science. Then, I follow the debate concerning Steele’s Lamarckian experiments with a closer look at Popper’s role and his position in this controversy. I conclude that Popper’s writings provided a new context for the discussion of Lamarckism in the 1970s and 1980s, thus making it “scientifically acceptable” again. I preface this discussion by a brief outline of Steele’s Lamarckian hypothesis and Popper’s comments on Steele’s work. (shrink)

The article examines science-policy conversations mediated by social science in attempts to govern, or set up terms for, scientific research. The production of social science research accounts about science faces challenges in the domains of emerging technosciences, such as nano. Constructing notions of success and failure, participants in science actively engage in the interpretation of policy notions, such as the societal relevance of their research. Industrial engagement is one of the prominent themes both in policy renditions of governable science, and (...) in the participants’ attempts to achieve societally relevant research, often oriented into the future. How do we, as researchers, go about collecting, recording, and analyzing such future stories? I examine a series of recent interviews conducted in a number of US universities, and in particular at a university campus on the West Coast of the United States. The research engages participants through interviews, which can be understood as occasions for testing the interpretive flexibility of nano as “good” scientific practice and of what counts as societal relevance, under what circumstances and in view of what kind of audiences. (shrink)

This paper addresses the phenomenological experience of precarity and vulnerability in racialized gender-based violence from a structural perspective. Informed by Indigenous social theory and anti-colonial approaches to intergenerational trauma that link settler colonial violence to the modalities of stress-inducing social, institutional, and cultural violences in marginalized women’s lives, I argue that philosophical failures to understand trauma as a functional, organizational tool of settler colonial violence amplify the impact of traumatic experience on specific populations. It is trauma by design. I explore (...) this through the history of the concept of trauma and its connection to tragedy. I give a brief overview of prominent theories of trauma and contrast these with the work of Indigenous feminist scholar Dian Million (2013), who highlights functional complicity of settler colonial institutions in shaping accounts of trauma in the west. I begin the piece with an important illustration of the kinds of lives and experiences that call for a politicized understanding of trauma in anti-colonial feminist theory. I end by offering an expansive notion of structural trauma that is a methodological pivot for conducting trauma-based gender-based violence research in a decolonial context, which calls for an end to narratives of trauma that are severed from the settler colonial project of Native land dispossession and genocide. [Volume 23, no.1]. (shrink)

The subject of the study. The article analyzes a number of aspects of Brahms' intermezzo Op. 119 No. 3 in order to detect non-classical tendencies manifested in the structure of the musical fabric and the principles of shaping in this work. Research methodology. In the course of the study, the method of holistic analysis was used, which includes consideration of the features of harmony, textural originality, thematic processes and form-forming patterns in the Brahms intermezzo Op. 119 No. 3. Elements of (...) comparative analysis were also applied. The scientific novelty of the work consists in the fact that as a result of the research it was possible to identify a number of non-classical qualities of Brahms' music, namely: the homogeneity of the sound fabric, a weak degree of differentiation of relief and background in texture, the absence of common forms of sound and passive fragments in musical form. The conceptual kinship of Brahms' principles of working with musical material with the technique of interpenetration of object and space, which became widespread in painting at the beginning of the XX century, was also discovered. Conclusions, the results obtained allow us to conclude that Brahms' intermezzo Op. 119 No. 3 implements a number of non-classical principles of working with musical material that anticipate the discoveries of composers of the Novovensky school. The results of the research can be used in the process of further study of Brahms' creativity and various theoretical aspects of music at the turn of the XIX–XX centuries, as well as in performing and pedagogical practice. (shrink)

In recent years postcolonial and decolonial feminisms have become increasingly salient in philosophy, yet they are often deployed as conceptual stand-ins for generalized feminist critiques of eurocentrism (without reference to the material contexts anti-colonial feminisms emanate from), or as a platform to re-center internal debates between dominant European theories/ists under the guise of being conceptually ‘decolonized’. By contrast, this article focuses on the specific contexts, issues and lifeworld concerns that ground anti-colonial feminisms and provides a brief survey of the literature. (...) Because the terms implicated in the analysis (Third World, transnational, women of color, postcolonial, decolonial and indigenous feminisms) are highly contested on their own, I only provide provisional and non-foundational histories and definitions for the purposes of resisting philosophical appropriations of anti-colonial feminist theory. (shrink)